Demonstration of the concept (SFR 2010/ISCD 2011)

 What is TBS? Correlations exist between TBS and Parfitt’s µ-architecture parameters from human bone samples

Is it possible to evaluate TBS from low resolution images? YES

Is it possible to evaluate TBS from DEXA images? YES

TBS DXA: What does TBS measure? Is this measure exact and reproducible?

 What does TBS measure from the DEXA? TBS is highly correlated to the bone µ-architecture parameters, no matter which bone densitometer is used.

Is there a link between TBS and the bone mechanical properties? YES

Is TBS reproducible? YES

TBS DEXA: Can TBS be used in routine clinical practice?

 Is TBS reproducible in patients?YES

Is TBS measure independent from the bone densitometer? NO

Is TBS altered by the presence of soft tissues ? NO

Is TBS altered by the presence of arthritis? NO

Does TBS diagnose osteoporotic fractures? YES

Can TBS predict osteoporotic fracture? YES

Can TBS help evaluating treatments’ effects? YES

Can TBS help evaluating secondary osteoporosis? YES

TBS DEXA: Normative population

  Is there a normative curve available with TBS? YES